Researchers identify target with potential to improve CAR T-cell therapy response in patients with blood cancers
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 11:16 ET (26-Oct-2026 15:16 GMT/UTC)
University of Maryland School of Medicine (UMSOM) Researchers have identified a target that may improve the response of CAR T-cell therapy, a treatment for patients with recurrent or difficult to treat blood cancers.
In a recent study published in Signal Transduction and Targeted Therapy, scientists found increased survival and tumor-fighting activity in lab and animal models when they blocked a specific protein in the modified cells.
Blood clotting is one of the body’s oldest survival mechanisms—a biological defense that has protected humans from dangerous bleeding for millions of years. But when severe injuries strike, nature’s solution can sometimes fall short. Now, researchers in the Paul M. Rady Department of Mechanical Engineering at CU Boulder are helping test a new type of engineered blood clot that forms faster and is more durable than the ones found in nature. The new technique could one day transform how doctors treat traumatic injuries and manage life-threatening blood loss.
“Alzheimer’s-Related Psychosis: Interdisciplinary Perspectives for Understanding and Responding to Delusions and Hallucinations” — the latest report in The Gerontological Society of America’s Insights & Implications in Gerontology series — underscores the clinical, emotional, and societal impact of psychosis in individuals living with Alzheimer’s disease and stresses the need for comprehensive, person-centered approaches to care.