Scientists discover a hidden RNA “aging clock” in human sperm
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-Jun-2026 01:15 ET (1-Jun-2026 05:15 GMT/UTC)
Recently, a research team led by Professor Zhang Jiachao from the College of Food Science and Engineering, Hainan University, published a new study in Science Bulletin entitled “Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects in a type 2 diabetes model.” This study directly addresses the long-standing challenge of the “microbial drug black hole” in the pharmacotherapy of metabolic diseases. The team successfully identified a tropical probiotic strain with dual “efficacy-enhancing and toxicity-reducing” properties, Bifidobacterium animalis subsp. lactis B960 (B960). For the first time, the researchers systematically elucidated the molecular mechanism by which this strain produces the functional metabolite Calenduloside E to synergistically enhance the therapeutic efficacy of glibenclamide while mitigating its adverse effects. Importantly, these findings were further validated using a human-derived gut–liver interconnected organ-on-a-chip platform that recapitulates key aspects of the human physiological microenvironment in vitro. Overall, this work provides an innovative strategy for the development of probiotic-based adjuvant therapies for the treatment of type 2 diabetes.
The mini review brings together emerging evidence showing that glial cells actively influence disease progression and treatment response. Once considered simple support cells, glia are now recognized as dynamic regulators of brain health, playing both protective and harmful roles in neural function.
Shingles vaccination not only protects against the disease but may also contribute to slower biological aging in older adults, according to a new USC Leonard Davis School of Gerontology study.
Using data from the nationally representative U.S. Health and Retirement Study, researchers examined how shingles vaccination affected several aspects of biological aging in more than 3,800 study participants who were age 70 and older in 2016. Even when controlling for other sociodemographic and health variables, those who received the shingles vaccine showed slower overall biological aging on average in comparison to unvaccinated individuals.
Anne Neilan, MD, MPH, of the Medical Practice Evaluation Center (MPEC) and Department of Medicine at Mass General Brigham, and Kevin Ard, MD, MPH, also of the Department of Medicine, are the lead and senior authors of a paper published in Sexually Transmitted Diseases, “Differences in Sexual Health Clinic Services by Age and Gender in Metropolitan Boston.”
January 20, 2026 – Insilico Medicine (“Insilico”, HKEX: 3696), a clinical-stage biotechnology company powered by generative artificial intelligence (AI), and Hygtia Therapeutics Co., Ltd., (Hygtia Therapeutics), today announced a co-development collaboration agreement for Insilico’s ISM8969 program. Through the partnership, the two parties aim to accelerate the global advancement of ISM8969—an orally available, brain penetrant NLRP3 inhibitor for Central Nervous System (CNS) disorders.
POSTECH Researchers Enhance Diagnostic Performance for Steatotic Liver Disease Through Ultrafast Ultrasound Microvascular Flow Imaging.