Adults with obesity losing weight with glucagon-like peptide-1 (GLP-1) receptor agonist medications significantly decreased their physical activity, which is essential to protect muscle, according to a study being presented Saturday at ENDO 2026, the Endocrine Society’s annual meeting in Chicago, Ill.

A study of a new AI model examining 30 years of routine electronic health records (EHR) data could improve screening for primary aldosteronism, a leading cause of high blood pressure that is often unrecognized but increases patients’ risk of cardiovascular complications, according to a study being presented Saturday at ENDO 2026, the Endocrine Society’s annual meeting in Chicago, Ill.

Researchers from Amsterdam UMC, in collaboration with other hospitals, have successfully completed the first-ever Phase 3 study of an in vivo CRISPR therapy. In this large-scale, double-blind Phase 3 trial, 80 patients with hereditary angioedema were randomized to receive either the CRISPR therapy or a placebo. CRISPR therapy is a medical technique that allows doctors to precisely modify errors in cellular DNA to treat specific hereditary diseases. Danny Cohn, leader of the research, is highly enthusiastic: "The study demonstrates that the therapy is genuinely effective and safe. This confirmation is exactly what regulatory authorities need to approve the very first in vivo CRISPR gene editing treatment for the market."

As more than 40% of American teenagers report persistent feelings of sadness or hopelessness, a leading child psychologist says grandparents and extended family have a vital role to play.

Researchers have developed a new way of testing for foetal abnormalities using a simple blood draw from the mother that is able to identify a very high proportion of the clinically relevant genetic variants that are currently only detectable by invasive testing.

Women with HIV most often die from preventable, trauma-related conditions like substance use and mental illness — not the virus itself. Yet, these leading causes are largely missing from official death records, according to new research by UC San Francisco.