The research team led by Professors Yubo Fan and Xufeng Niu at Beihang University systematically investigated the changes in collagen fibers within atherosclerotic plaques by establishing an ApoE knockout mouse model fed with a high-fat diet, combined with histological staining, immunohistochemistry, and in vitro experiments. Their findings revealed a progressive decline in CFA orientation as AS advanced, with regions of randomization coinciding with inflammatory responses, smooth muscle cell (SMC) phenotype switching, osteogenic gene expression, and vascular calcification. These results highlight CFA as a valuable indicator for delineating lesion regions and assessing disease stages, thus providing theoretical support for early diagnosis and therapeutic intervention.

Results of the NRG Oncology NRG-GU005 clinical study comparing stereotactic body radiation therapy (SBRT) to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) for patients with localized immediate risk prostate cancer indicate that the use of SBRT improved bowel health related quality of life (HRQOL) in this patient population. There was no significant improvement seen for the other primary objectives including urinary HRQOL and there was a lack of improvement in distant-free survival for patients.

The largest study of its kind has found menopause is not associated with an increased risk of disability in women with multiple sclerosis (MS). Until now, the impact of reduced sex hormones on women with MS had only been the subject of small studies, some with conflicting results.