Blocking a key inflammatory pathway improves liver structure and vascular function in cirrhosis, study finds
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Jun-2026 17:16 ET (16-Jun-2026 21:16 GMT/UTC)
Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage. Published in Biomedicine & Pharmacotherapy, the study shows that blocking this pathway improves liver structure and vascular function, highlighting a promising target for future cirrhosis therapies.
“Tiny biological batteries” can change the cell membrane’s electrical properties—a discovery that has big implications for health, as many essential cellular processes hinge upon precise electrical activity.
Fertility rates in much of Sub-Saharan Africa remain high, despite declining child mortality and improved access to contraceptives and female education — factors that generally lead to smaller families and improved economic conditions in developing countries. A new study from the University of Illinois Urbana-Champaign looks at men’s and women’s desired fertility in rural Tanzania, gauging some of the factors that influence how many children they want.