Pusan National University researchers develop tool to improve CRISPR off-target predictions using genetic variants
Peer-Reviewed Publication
Updates every hour. Last Updated: 17-Sep-2025 23:11 ET (18-Sep-2025 03:11 GMT/UTC)
CRISPR-based gene editing holds great promise, but off-target effects remain a major concern, especially across diverse genetic backgrounds. A new study presents a web-based tool that enhances off-target site prediction by incorporating individual genetic variants. Developed using the human genome and pepper plant cultivars, the tool improves accuracy at the haplotype level. This user-friendly, login-free platform offers researchers a powerful way to personalize and safeguard genome editing applications across fields.
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