Epithelial ovarian cancer (EOC) is an aggressive malignancy with limited therapeutic options. Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown remarkable efficacy, especially in BRCA-mutant patients, and are approved as maintenance therapy to prevent recurrence after initial response to chemotherapy.

Research groups of Professors Weiqi Zhang, Haiyan Xu and Lin Wang from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, reported a positively-charged dextran nano-photosensitizer (p-Dex PS) facilitates tumor-associated macrophage (TAM)-mediated delivery and sublethal light-induced metabolic reprogramming, which boosts the TAM polarization and subsequently the anticancer immune effects.

Harvard engineers, as part of Project CETI, have built an open-source bio-logger that adheres to sperm whales and records high-fidelity, multi-channel audio plus rich behavioral and environmental data. The data are tailored for machine learning analysis so that researchers can better understand whale communication.

Scientists at Aarhus University have developed nanomotors inspired by the bacterium Listeria monocytogenes and placed them inside artificial cells. The nanomotors drive the formation of internal protein networks resembling a cytoskeleton, giving artificial cells a life-like function previously seen only in living cells and marking a step toward self-organizing synthetic systems.