Rethinking coupling methods for more sustainable organic synthesis
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-May-2025 01:08 ET (1-May-2025 05:08 GMT/UTC)
Coupling reactions are essential in the synthesis of pharmaceuticals, agrochemicals, and advanced materials, but traditional methods often rely on costly and environmentally taxing transition metal catalysts. Now, researchers from Japan have reviewed emerging transition metal-free alternatives that align better with green chemistry principles. Their study highlights hypervalent iodine-mediated coupling, a strategy that enables selective bond formation without rare metals. By leveraging diaryliodonium salts, this approach can greatly enhance efficiency and reduce waste in coupling reactions.
Several prominent phenomena of condensed matter, exemplified by nonlinear transport, flat-band superconductivity, and fractional Chern insulators, are systematically reviewed with a focus on their quantum geometric origins.
Researchers have reviewed metamaterials to emulate Schrödinger dynamics, bridging classical wave physics and quantum phenomena. Such analog enables robust wave manipulation and explores quantum behaviors beyond electronic systems, promising breakthroughs in imaging, sensing, and energy technologies.
In a paper published in Science Bulletin, an international team of physicists from Singapore and China demonstrates how quasi-bound states in the continuum (QBICs) can induce abrupt lateral beam shifts in the terahertz regime. By applying Brillouin zone folding to a compound grating waveguide, the researchers created a QBIC band that enables sudden and significant beam shifts, offering new insights into real-space QBIC properties and potential applications in sensing and wavelength multiplexing.
This work developed a new deep learning framework, MULGONET, to predict cancer recurrence and identify key biomarkers by integrating multi omics data (such as mRNA, DNA methylation, copy number variation). By utilizing the gene ontology (go) hierarchy, the model overcomes the challenges of data dimensionality and interpretability, and achieves higher accuracy in bladder cancer, pancreatic cancer, and gastric cancer datasets. This innovation enables clinicians to pinpoint key genes and biological pathways associated with cancer recurrence, paving the way for personalized treatment strategies.
Black holes are fundamental to the structure of galaxies and critical in our understanding of gravity, space, and time. A stellar mass black hole is a type of black hole that forms from the gravitational collapse of a massive star at the end of its life cycle. These black holes typically have masses ranging from about 3 to 20 times the mass of our Sun.
Sometimes black holes generate beams of ionized gas (plasma) that shoot outward at nearly light speed. Although discovered more than a century ago, how and why jets occur has remained a mystery, described as one of the “wonders of physics”.
Prof. Kazutaka Yamaoka from Nagoya University in Japan, along with his colleagues from University of Toyama and other international institutes, have discovered key conditions needed for a stellar black hole to create plasma jets. Their findings, published in Publications of the Astronomical Society of Japan, show that when superheated gas material experiences a rapid shrinkage towards the black hole, jet formation occurs.