For the ArchaeoSpain research team, it was a day just like any other on their dig at the castle of Zorita de los Canes (Guadalajara). They were working at the Corral de los Condes, where some knights from the Order of Calatrava are buried, when they came across some highly unusual human remains. Accompanying an apparently normal adult skeleton, was an extraordinarily narrow and elongated skull, 23 centimetres long and only 12 centimetres wide. Who was this individual and how did they survive to adulthood? What caused such a severe cranial deformity? What role did they play in the Order of Calatrava? To answer these questions, the team sent the skeleton to the laboratory of Carme Rissech, a researcher in the Department of Basic Medical Sciences at the URV.

The correlation between Arctic wildfires and abnormal snow cover under global warming is of growing concern. A comprehensive quantitative assessment by researchers at The Hong Kong Polytechnic University (PolyU) has shown that increasingly frequent seasonal wildland fires across the Arctic in recent years have delayed snow cover formation by at least five days and could lead to a future 18-day reduction of snow cover duration, with implications for global ecosystems. Against the backdrop of the United Nation’s “Decade of Action for Cryospheric Sciences”, this study not only underscores the urgency of addressing climate change, but also provides critical scientific evidence to inform global climate adaptation strategies.

This feature explores how European education systems negotiate tensions between collective ideals and growing competition. Drawing on studies from Denmark, Sweden, Norway, and Belarus, it examines shadow education, policy debates over equity, culturally grounded early childhood learning, and enduring post-Soviet public institutions. Together, these perspectives reveal education as a social mirror, continuously balancing public good, cultural identity, historical legacy, and individual ambition across diverse European contexts and shared societal values.

Small interfering RNA (siRNA) has shown promising therapeutic prospects in many major diseases. However, two main reasons limit the application of siRNA: poor endocytosis efficiency and weak endosomal escape ability. Therefore, the development of efficient and safe delivery vectors has always been an important study aspect of RNAi technology. Herein, we designed a self-assembled nanoparticle based on functionalized peptides to deliver siRNA to the down-regulated polo-like kinase 1 (PLK1) gene, which can inhibit tumor cells in the G2 phase. The functional polypeptide consists of cell membrane-penetrating peptide (CPP44) and p16 minimal inhibitory sequence (p16MIS). CPP44 can effectively mediate endocytosis, while p16MIS can inhibit tumor growth in the G1 phase and synergistically promote the apoptosis of tumor cells with siPLK1. In vitro and in vivo studies demonstrate that the developed nanoparticle exhibits high levels of silencing efficiency, antitumor activity, and therapeutic efficacy. Consequently, this study provides a novel approach to cancer treatment by simultaneously disrupting two stages of tumor cell division.

This study presents a metamaterial-inspired design to develop negative Poisson's ratio (NPR) structural electrodes using a directional freezing 3D printing-assisted strategy. This approach incorporates both macroscopic NPR structures and microscopic directional porous structures, which enhances ion transport, improves compressibility and provides impact resistance, effectively preventing package bulges during compression. Consequently, the electrodes demonstrate a high 50% compressible deformation and recover their original state even after 50 cycles of 25% compression. The 3D-printed lithium iron phosphate cathodes deliver a high average specific capacity of 153 mAh/g over 100 cycles and exhibit outstanding rate capability. Furthermore, the assembled full cell maintains both excellent compressibility and impact-buffered resistance, highlighting its potential applications. This innovative design of NPR metamaterial-structured electrodes provides a universal platform for developing the next generation of impact-buffered, compressible structural batteries.

Researchers at Kumamoto University have demonstrated that iron supplementation can significantly alleviate muscle pathology and functional decline in a mouse model of facioscapulohumeral muscular dystrophy (FSHD), a rare genetic muscle disease for which no effective treatment currently exists.

Petal size is a defining trait of ornamental flowers, directly shaping visual appeal and commercial value. 

Sterol regulatory element-binding protein 1 (SREBP1), a key regulator of lipogenesis, is highly expressed in tumors, but the mechanisms sustaining its elevated levels remain unclear. The role of UFMylation, a posttranslational modification, in modulating SREBP1 stability and tumor progression has not been explored. This study aimed to investigate the role of UFMylation in the progression of liver cancer.