A research team has developed a long-acting injectable treprostinil depot that forms a drug-releasing gel inside the body, providing sustained pulmonary vasodilation for three to four days after a single intramuscular injection in rats with pulmonary arterial hypertension (PAH).

A new study challenges one of the most deeply rooted assumptions in civil engineering: that using recycled materials in structural concrete inevitably means sacrificing strength. Researchers from Escuela Superior Politécnica del Litoral, in collaboration with University of Surrey, have demonstrated that recycled aggregates can be incorporated into concrete without compromising performance—provided certain technical limits are respected.

Airborne genetic material could transform biodiversity and biosecurity monitoring, but researchers say major gaps in sampling, interpretation, and governance must be closed first before suitable technologies can be deployed.

Our findings demonstrate that hnRNPA2B1-dependent m⁶A modification of circSMAD6 accelerates aerobic glycolysis and metastasis of HCC cells by regulating miR-30d-3p/CNPY2 axis, and may provide a potential therapeutic target for HCC.

Repeated IVF-ET failure in women of advanced maternal age is a key and difficult issue in assisted reproduction. At present, the evidence base for many therapeutic approaches in this population remains relatively weak, and the appropriate patient populations for TCM intervention, the optimal timing of such interventions, and its positioning within the overall diagnostic and treatment framework still need to be further clarified.   The value of this article lies in distilling a diagnostic and therapeutic approach centered on sequential phase-based TCM treatment and coordinated mind-body regulation.

With the continuous advancement of spaceborne synthetic aperture radar (SAR) technology, L-band SAR has come to play an increasingly important role in Earth observation; however, its imaging, interferometric, and polarimetric performance are susceptible to ionospheric disturbances. In equatorial nighttime data, amplitude streak artifacts induced by equatorial plasma bubbles frequently occur and have traditionally been regarded as interference factors in SAR imaging. Nevertheless, these artifacts essentially carry critical information on ionospheric irregularities and can be exploited to retrieve physical parameters such as scintillation intensity and turbulence spectral indices. Existing methods either rely on comparisons between disturbed and undisturbed images or are limited to preliminary one-dimensional parameter estimation along the track, making it difficult to achieve two-dimensional fine-scale retrieval of scintillation structures, and lacking systematic validation of their spatial correlation with equatorial ionospheric anomalies. Therefore, how to extract the two-dimensional spatial distribution of ionospheric scintillation parameters from amplitude streak artifacts and reveal their intrinsic relationship with regions of enhanced electron density has become an important scientific question in the field of ionospheric remote sensing.