5-Jan-2026
New mechanism reveals how HTLV-1 triggers aggressive leukemia
Kumamoto UniversityResearchers at Kumamoto University have uncovered a previously unknown molecular mechanism by which human T-cell leukemia virus type I (HTLV-1) drives the development of adult T-cell leukemia-lymphoma (ATL), one of the most aggressive and difficult-to-treat blood cancers. The findings provide critical insight into why only a small fraction of HTLV-1 carriers develop leukemia—and point toward new strategies for targeted therapy.
- Journal
- Proceedings of the National Academy of Sciences
- Funder
- Japan Agency for Medical Research and Development, Japan Agency for Medical Research and Development, Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science, Japan Society for the Promotion of Science, SGH Foundation, Japan Science and Technology Agency