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Article Highlights

Updates every hour. Last Updated: 27-Oct-2026 14:17 ET (27-Oct-2026 18:17 GMT/UTC)

Metabolomic profiling defines subtype-specific programs in pediatric ependymoma

Higher Education Press

Ependymoma is a central nervous system tumor that occurs primarily in children and can arise in the supratentorial region, posterior fossa, or spinal cord. Although molecular classification has substantially improved disease stratification and prognostic assessment, the metabolic phenotypes associated with the major pediatric subtypes have remained poorly defined. Because pediatric ependymoma is rare, assembling a cohort that spans multiple molecularly defined subtypes for systematic metabolic comparison is itself challenging.

Journal: Life Metabolism

Age shapes the cardiovascular impact of ABC risk factors in diabetes: Insights from the 4C Cohort

Higher Education Press

Diabetes is a highly prevalent chronic condition and a major contributor to the global burden of disease, posing substantial challenges to health systems. Cardiovascular disease (CVD) remains its leading complication, and people with diabetes face a two- to four-fold higher risk of cardiovascular morbidity and mortality than the general population. Control of glycated hemoglobin (HbA1c), blood pressure, and low-density lipoprotein cholesterol (LDL-C), collectively referred to as ABC risk factors, is a cornerstone of cardiovascular prevention in diabetes.

Journal: Life Metabolism

Fasting turns brain lysosomes into reservoirs for TCA cycle metabolites

Higher Education Press

Lysosomes were once viewed mainly as cellular waste disposers, but are now recognized as key hubs for nutrient sensing and metabolic signaling. Still, what lysosomes contribute metabolically inside high-demand neurons in the intact brain remains elusive.

Journal: Life Metabolism

A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction

Higher Education Press

Aging is a major risk factor for chronic diseases, and calorie restriction (CR) is a robust non-pharmacological intervention that can extend health span in multiple species. Alternative splicing (AS) generates multiple RNA isoforms from a single pre-mRNA and becomes dysregulated with age; intriguingly, prior work suggests that CR can attenuate age-associated splicing noise. What has remained unclear is whether AS responses to CR are coordinated across tissues and whether they scale with the level of restriction.

Journal: Life Metabolism

Gestational progesterone is linked to improved menstrual regularity after

Higher Education Press

Polycystic ovary syndrome (PCOS) affects 6%−20% of reproductive-aged women, and is commonly accompanied by irregular menstrual cycles and anovulatory infertility. The mechanisms underlying menstrual cycle irregularities associated with PCOS, and how they may change after pregnancy remain incompletely understood.

Journal: Life Metabolism

Integrating heart imaging and proteomics identifies drug targets for cardiovascular diseases

Higher Education Press

As an emerging branch of clinical medicine, microbiota medicine has attracted worldwide attention from clinicians, medical educators, patient communities, and industry. However, this developing field still lacks consensus on its fundamental principles as well as guidelines for clinical and educational practice. An expert panel was convened by the journal Microbiota Medicine Research at the 2025 CHINAGUT Conference to develop the principles and practice guidelines of microbiota medicine.

FPR2 drives intestinal epithelial repair after injury

Higher Education Press

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at the base of crypts. While ISCs play an essential role in epithelial regeneration following injury, such as that induced by chemotherapy or radiation, the underlying regulatory mechanisms remain incompletely understood.

Journal: Life Metabolism

Post-meal SPARC level predicts who benefits most from the Mediterranean diet

Higher Education Press

A new study published in Life Metabolism reports that a single post-meal blood biomarker, 1-hour postprandial SPARC (SPARC-1H), can predict who will benefit most from adopting a Mediterranean diet. The discovery provides one of the clearest examples to date of how precision nutrition can identify individualized dietary responses using a simple blood test rather than complex multi-omics models.

Journal: Life Metabolism

Molecular characterization of HIV-1 subtypes and primary drug resistance mutations in Bangladesh: Insights from 2019 data

Bentham Science Publishers

Acquired Immunodeficiency Syndrome (AIDS) caused by Human Immunodeficiency Virus (HIV) has been a significant public health concern for over four decades. Globally, more than 75 million individuals have been infected, with an estimated 32.7 million deaths attributed to AIDS-related complications. Even though there are continuous advancements in treatment and prevention, in 2019, about 1.7 million new infections were reported, which represents a 23% decline in new diagnoses compared to 2010, The high frequency of the D121 polymorphism, though not directly linked to treatment failure, reflects underlying genetic variability that may influence future resistance pathways

Journal: The Open AIDS Journal

Glycine acts as a signal to boost insulin secretion via ER calcium homeostasis

Higher Education Press

Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies consistently show that reduced circulating glycine levels are associated with insulin resistance, type 2 diabetes (T2D), and obesity across diverse populations. However, the molecular mechanism linking glycine to insulin production has remained incompletely understood, limiting therapeutic applications.

Journal: Life Metabolism

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