Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People’s Hospital, published a review entitled “Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer”. Aligned with the paradigm shift toward precision medicine and individualized management in prostate cancer, this review systematically summarizes the adaptive changes in intratumoral androgen metabolism and androgen receptor (AR) signaling during disease progression from hormone-sensitive prostate cancer (HSPC) to castration-resistant prostate cancer (CRPC) and the highly aggressive subtypes (DNPC and NEPC) emerging during castration resistance, along with research advances in how these mechanisms contribute to therapy resistance. Furthermore, the review critically analyzes current challenges in studying prostate cancer resistance, and outlines future directions toward high-throughput, refined, and personalized strategies, emphasizing the integration of multi-omics technologies and novel in vitro and in vivo models to advance mechanistic insights into drug resistance, thereby establishing a scientific foundation for optimizing individualized therapeutic approaches.

After a stroke, nearly half of patients struggle to swallow – a dangerous condition called post-stroke dysphagia (PSD) that can lead to malnutrition, pneumonia, or even death. 

Researchers from Ben-Gurion University of the Negev (BGU) have found that how quickly an older adult can execute a voluntary step—especially when distracted (concurrently performed cognitive task)—may serve as a valuable clinical predictor of survival. The explorative study suggests that dynamic balance assessments capture an integration of neuromuscular vitality and central cognitive processing, offering a window into an individual's long-term functional health.

A new review shows that AI, teledermatology, and mobile follow-up tools can help family doctors in China manage chronic skin diseases and related mental health and metabolic issues—shifting care from one-off visits to continuous, whole-life support.

Idiopathic pulmonary fibrosis remains a hard-to-treat lung disease with limited effective drugs. A recent study in Engineering used machine learning to screen natural compounds and found dihydromyricetin, a flavonoid from herbs, can block the TGF-β/ALK5 signaling pathway. It alleviates fibrosis and inflammation in cell and mouse models, shows good safety, and offers a new natural-product-based direction for pulmonary fibrosis treatment.