Berberine and leaky gut
Wroclaw Medical UniversityWe often treat intestinal infections as short episodes. Yet for many patients, symptoms such as bloating, abdominal pain, and unstable bowel movements persist long after the pathogen disappears.
Researchers from Wroclaw Medical University, in a study published in the International Journal of Molecular Sciences, show that during infection with Campylobacter jejuni, “leaky gut” is not a metaphor but a measurable disruption of the intestinal barrier.
The bacteria destabilize tight junctions — microscopic connections between epithelial cells that control intestinal permeability. Even after the infection resolves, this barrier may remain weakened, sustaining inflammation and prolonged symptoms.
In a colonic model, berberine demonstrated dual action: it limited bacterial growth and biofilm formation, while simultaneously protecting epithelial integrity and reducing permeability. Although further clinical studies are needed, the findings suggest that effective recovery from infection should focus not only on eliminating the pathogen, but also on restoring the intestinal barrier.
- Journal
- International Journal of Molecular Sciences