A new study published in Engineering reveals that dihydrotanshinone I (DHT), a compound from Salvia miltiorrhiza, can induce autophagic cell death in ovarian cancer by targeting sortilin 1 (SORT1). This discovery offers a potential new therapeutic strategy for treating ovarian cancer through disrupting the autophagy–lysosome pathway.

Thermoelectric technology that utilizes thermodynamic effects to convert thermal energy into electrical energy has greatly expanded wearable health monitoring, personalized detecting, and communicating applications. Encouragingly, thermoelectric technology assisted by artificial intelligence exerts great development potential in wearable electronic devices that rely on the self-sustainable operation of human body heat. Ionic thermoelectric (i-TE) devices that possess high Seebeck coefficients and a constant and stable electrical output are expected to achieve an effective conversation of thermal energy harvesting. Herein, we developed an i-TE paster for thermal chargeable energy storage, temperature-triggered material recognition, contact/non-contact temperature detection, and photo thermoelectric conversion applications. An all-solid-state organic ionic gel electrolyte (PVDF-HFP-PEO gel) with onion epidermal cells-like structure was sandwiched between two electrodes, which take full advantage of a synergy between the Soret effect and the polymer thermal expansion effect, thus achieving the enhanced ZT value up to 900% compared with the PEO-free electrolyte. The i-TE device delivers a Seebeck coefficient of 28 mV K⁻¹, a maximum energy conversion efficiency of 1.3% in performance, and ultra-thin and skin-attachable properties in wearability, which demonstrate the great potential and application prospect of the i-TE paster in self-sustainable wearable electronics.

Scientists present a new approach that could empower the immune system to combat cancer cells and pave the way for new treatments for this deadly disease. The new insight stems from an extensive review of research on TIGIT, a protein known to inhibit the immune system’s ability to effectively attack cancer cells. Currently, a single drug can successfully neutralize TIGIT and enable immune cells to combat cancer in laboratory settings; however, clinical trials have been less successful.

Mass spectrometry (MS) is an analytical technique for molecular identification and characterization, with applications spanning various scientific disciplines. Despite its significance, MS faces challenges in widespread adoption due to cost constraints, instrument portability issues, and complex sample handling requirements. In recent years, 3D printing has emerged as a technology across industries due to its cost-effectiveness, customization capabilities, and rapid prototyping features. This review explores the integration of 3D printing with MS technology to overcome existing limitations and enhance biomedical analysis capabilities. We first categorize mainstream 3D printing methods and assess their potential in MS applications. We also discuss their roles in different MS categories such as liquid chromatography mass spectrometry (LCMS), gas chromatography mass spectrometry (GCMS), ambient ionization mass spectrometry (AIMS), and matrix-assisted laser desorption/ionization MS (MALDI MS) in biomedical research. Additionally, we highlight the current challenges and future research directions for advancing 3D printing-assisted mass spectrometry, emphasizing its role in enabling portable, cost-effective, and customized MS solutions for biomedical analysis.

Following the path towards innovation in education and health, the Department of Education and Specific Didactics of the Universitat Jaume I is developing Hort4Health. Under the direction of Mireia Adelantado Renau, lecturer in the Department of Didactics of Experimental Sciences, this leading project seeks to analyse and investigate in an interdisciplinary way the impact of integrating an eco-educational garden in the classrooms where students learn about health, sustainability and emotional well-being, thus offering a solid scientific basis on the benefits of these practices.

The Hort4Health project emerges in response to the growing need to promote healthy habits among young people, especially in an era where technology and sedentary lifestyles predominate and generate worrying figures. Through practical activities in the garden, students not only study about agriculture and ecology, but also experience the benefits of physical activity and contact with nature for their mental and physical health. Researcher Mireia Adelantado points out that in this way "scientific results will be obtained on the current healthy habits of the university community, completing the scarce previous literature on this subject in this population". This initiative has already involved more than a hundred pupils from the Early Childhood and Primary School Teacher degrees, who have participated in sessions designed to improve their emotional wellbeing, their connection with the environment and their understanding of the importance of an active and healthy life. Early results indicate a significant positive impact on the physical health of the participants and underline the potential of the garden as an innovative space for learning and wellbeing.

As Alzheimer’s disease (AD) becomes more prevalent, scientists are exploring new methods for its early detection. In a recent review, researchers from India outline how neuron-derived extracellular vesicles—tiny membrane-bound particles released by neurons—are emerging as a promising diagnostic tool for AD. The contents of these vesicles carry molecular clues on the health of neurons, and it may soon be possible to use them to predict the onset of AD several years in advance.