Duraplasty is a surgical procedure that is used to repair or reconstruct the dura mater using a patch graft. Several graft materials are used for the surgery, but their comparative safety remains uncertain. Now, researchers conducted a prospective randomized study in Central India to compare the outcomes of autologous pericranium (natural graft) with those of synthetic high-density polypropylene (G-Patch) in patients undergoing cranial duraplasty. Findings confirmed that both materials demonstrated acceptable short-term safety profiles.