Calls to poison centers involving liver injuries caused by medications, supplements, alcohol and other substances jumped nearly 400% between 2000 and 2024, according to a new study from UVA Health. 

A study of non-functional pancreatic neuroendocrine tumors (NF-PanNETs) identified an AGR2^high endocrine subcluster enriched in high-grade tumors and showed that simple AGR2 immunohistochemistry serves as a clinically informative prognostic marker. Mechanistically, the transcription factor FOXM1 directly drives the proliferative transcriptional program of AGR2^high cells, while chemical inhibition of FOXM1 showed therapeutic benefit in tumor cells, patient-derived organoids, and xenograft models. Together, the findings provide a new approach for prognostic stratification and identify FOXM1 as a potential therapeutic vulnerability in NF-PanNETs.

Established Alzheimer’s markers are also detected in blood samples from Nigeria and Tanzania. But other proteins in the blood differ from those seen in a comparable group in Canada. This is important if blood tests for Alzheimer’s are to be used globally.

Most individuals encounter their health primarily through an annual health screening, which provides a limited snapshot of one’s health status. A new study by the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), is challenging the way we think about health and longevity, by seeking to understand what occurs between those assessments, focusing on function rather than static markers, tracking how physiology changes moment to moment.

Led by Professor Dean Ho, Director of the Institute for Digital Medicine (WisDM) at NUS Medicine, the study took an unusual and highly personalised approach: Prof Ho became the sole subject of the study.