Researchers from the EHU-University of the Basque Country have developed a robust protocol to detect the molecules involved in the metabolic reactions of sperm. The new method enables a detailed analysis to be made even with small samples, and the largest number of potential biomarkers identified to date to be detected; this advance could help to diagnose male infertility and develop future clinical solutions.

Researchers at the University of Tartu showed that large language models can identify, with high accuracy, why patients stop using antidiabetic medications or statins, based on doctors’ electronic clinical notes. The study opens new possibilities for using clinical information that has so far been difficult to analyse in health research.

Cancers caused by mutations in the KRAS gene are challenging to treat, and current KRAS inhibitor therapies can leave behind reversible drug-tolerant persister (DTP) cells that survive therapy, contributing to tumor regrowth and relapse. Researchers from Chiba University found that these surviving cells adapt by reshaping their metabolism. By targeting these metabolic adaptations, the team succeeded in reducing the survival of DTP cells. The findings may help develop therapies to reduce relapse in KRAS-mutant cancers.