This peer-reviewed Perspective synthesizes a decade of research on a surprising candidate for autism science: the laboratory Beagle. Drawing together scattered studies, the review authors argue that dogs carrying engineered changes in the Shank3 gene reproduce core human features of autism spectrum disorder, including social withdrawal, altered sensory responses, and reduced attention to the eyes of a face. The synthesis assembles, for the first time in one place, the parallels between mutant dogs and autistic people, alongside early signals that oxytocin, a psychedelic, and a third compound may soften these traits. The authors frame the dog as a complementary, ethically governed model, not a replacement for existing ones.

A comprehensive review highlights how TP53 mutations contribute to oral cancer development, treatment resistance, and poor patient outcomes. The study summarizes emerging therapeutic approaches, including mutant p53 reactivation, synthetic lethality, and immunotherapy-based strategies, providing new perspectives for precision medicine in oral cancer.A comprehensive review highlights how TP53 mutations contribute to oral cancer development, treatment resistance, and poor patient outcomes. The study summarizes emerging therapeutic approaches, including mutant p53 reactivation, synthetic lethality, and immunotherapy-based strategies, providing new perspectives for precision medicine in oral cancer.

Human fetal tissue research has contributed significantly to our understanding of human development and continues to support progress in regenerative medicine. However, the use of fetal tissue obtained following induced abortion raises important ethical considerations. In 2022, the International Society for Stem Cell Research (ISSCR) published standards for obtaining informed consent for fetal tissue donation. At present, Japan has no laws or guidelines that specifically govern fetal tissue research.

A research group led by Professor Misao Fujita, Professor Mitinori Saitou, and Professor Yasuhiro Takashima of the Institute for the Advanced Study of Human Biology (WPI-ASHBi) and the Center for iPS Cell Research and Application (CiRA) at Kyoto University has examined the ethical, legal, and social issues surrounding human fetal tissue research in Japan. Drawing on an analysis of legal frameworks, regulations, and social contexts in Japan and other countries, the authors identified three key challenges in applying the ISSCR standards domestically: (1) minimizing burdens on potential donors; (2) determining the role of male partners in decisions regarding fetal tissue donation; and (3) addressing legal uncertainties surrounding the storage, use, and disposal of fetal tissue. The study proposes possible approaches to each of these issues.

These findings were published online in Regenerative Medicine on 11 June 2026.