Menopause linked to loss of grey matter in the brain, poorer mental health and sleep disturbance
Peer-Reviewed Publication
Updates every hour. Last Updated: 17-Jun-2026 17:15 ET (17-Jun-2026 21:15 GMT/UTC)
Menopause is linked to reductions in grey matter volume in key brain regions as well as increased levels of anxiety and depression and difficulties with sleep, according to new research from the University of Cambridge. The study, published today in Psychological Medicine, found that hormone replacement therapy (HRT) does not appear to mitigate these effects, though it can slow the decline in reaction times.
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