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Updates every hour. Last Updated: 20-Aug-2025 20:11 ET (21-Aug-2025 00:11 GMT/UTC)
Pepper’s fertility puzzle solved: gene discovery unlocks hybrid potential
Nanjing Agricultural University The Academy of ScienceHybrid pepper breeding has long hinged on cytoplasmic male sterility (CMS) systems, but a lack of functional restorer genes has left a critical gap.
- Journal
- Horticulture Research
Study reveals key role of AcrAB and OqxAB efflux pumps in ciprofloxacin resistance of Klebsiella pneumoniae
FAR Publishing LimitedA new study highlights the critical role of AcrAB and OqxAB efflux pumps in ciprofloxacin resistance among Klebsiella pneumoniae clinical isolates. Researchers found overexpression of these pumps and their regulators significantly contributes to multidrug resistance, offering insights for future therapeutic strategies.
New research unveils key molecular pathways in diabetic neuropathy and nephropathy
FAR Publishing LimitedA comprehensive review by researchers at Teerthanker Mahaveer University highlights critical molecular pathways—including PKC activation, oxidative stress, and inflammatory cytokines—driving diabetic neuropathy and nephropathy. The study identifies potential therapeutic targets to combat these debilitating complications.
- Journal
- Current Molecular Pharmacology
Novel miR-451/ETV4/MMP13 signaling axis identified as key driver of non-small cell lung cancer progression
FAR Publishing LimitedA study by Tianjin First Central Hospital researchers reveals the miR-451/ETV4/MMP13 signaling axis as a critical regulator of NSCLC progression. Findings show miR-451 suppression activates ETV4-MMP13, driving tumor growth and metastasis, offering new therapeutic targets.
- Journal
- Current Molecular Pharmacology
Novel network medicine approach identifies potential drug candidates for abdominal aortic aneurysms
FAR Publishing LimitedA groundbreaking study by researchers at Zhengzhou University reveals a computational framework to identify key inflammatory genes and drug candidates for abdominal aortic aneurysms (AAA). Using single-cell RNA sequencing and molecular docking, the team pinpointed SLC2A3 as a critical target and DB08213 as a promising therapeutic compound.
- Journal
- Current Molecular Pharmacology
Novel circRNA hsa_circ_0000021 identified as key driver of cervical cancer progression
FAR Publishing LimitedA study led by researchers at the General Hospital of Western Theater Command reveals that hsa_circ_0000021 promotes cervical cancer (CC) progression by sponging miR-3940-3p and upregulating KPNA2. Findings suggest this circRNA as a potential therapeutic target for CC treatment.
- Journal
- Current Molecular Pharmacology
SlTOR negatively regulates cold stress responses
Nanjing Agricultural University The Academy of SciencePlants often face a trade-off between growing and surviving under stress. In this study, researchers uncovered how the target of rapamycin (TOR) kinase in tomatoes plays a central role in navigating this balance.
- Journal
- Horticulture Research
Engineered vesicles emerge as a promising drug delivery system in antiviral therapy
Shanghai Jiao Tong University Journal CenterAkkermansia muciniphila (Akk) has gained significant attention for its role in regulating metabolic health and its impact on diseases such as cancer, diabetes, obesity, and inflammatory bowel disease (IBD). Studies suggest that the regulatory effects of Akk are primarily realized through its secreted extracellular vesicles (Akk-EVs), rather than relying solely on the in vivo form. These highly stable bilayer vesicles can regulate physiological and pathological processes in host cells through local or systemic signaling. Unlike direct delivery by live bacteria, Akk-EVs can efficiently deliver a variety of bioactive molecules involved in the regulation of glucose metabolism, lipid homeostasis, intestinal immunity, and maintenance of intestinal barrier integrity without the risk of infection. Given that natural and engineered EVs are increasingly entering clinical trials, Akk-EVs, with their superior stability and specificity, present a promising therapeutic alternative to live bacterial treatments. This review summarizes the regulatory mechanisms of Akk-EVs in health and disease and discusses their potential applications in precision medicine and clinical therapy, offering new insights into therapeutic strategies for metabolic disorders, cancer, and gut diseases.
- Journal
- LabMed Discovery
Advances in von Willebrand disease diagnosis
Shanghai Jiao Tong University Journal CenterVon Willebrand disease (VWD) is caused by a quantitative or qualitative defect of von Willebrand factor (VWF). Despite its prevalence as the most common hereditary bleeding disorder and the associated morbidity, its diagnosis and classification remains a challenge. This is mainly attributed to the heterogeneity of the disorder, multi-faceted functions of VWF, limitations of diagnostic assays, and significant impacts of various patho-physiological processes on VWF. For the past few years, significant progress has been made in elucidating the structural basis of VWF activation and development of VWF activity assays. The O-glycosylated sequences flanking the VWF A1 domain constitute a discontinuous and force-sensitive autoinhibitory module (AIM), which regulates the VWF affinity for GPIbα. New options for laboratory assessment of VWF activity include VWF∶GPIbM and VWF∶GPIbNab. The former utilizes a recombinant gain-of-function GPIbα fragment that supports spontaneous binding to plasma VWF, with less variability and higher precision compared to the traditional ristocetin cofactor activity assay. The latter utilizes a VWF-activating nanobody targeting the AIM to activate VWF, demonstrating the highest sensitivity for high-molecular-weight multimers among contemporary assays in the preliminary study. In this review, we focused on recent developments in the field of VWD diagnosis and considered how these advances can improve diagnostic algorithms and patient care in clinical practice.
- Journal
- LabMed Discovery