Philippine Studies: Historical and Ethnographic Viewpoints has just published its latest issue, The Limits of Liberalism.

CVD is driven by a dynamic IICM network, not by isolated, linear signaling pathways. The disease course is determined by the state of the immune network, which is dependent on context and time.

The dynamic balance between pro-inflammatory and reparative immunity directly determines the outcomes of CVD, including disease progression, plaque stability, and myocardial remodeling.

Inflammatory biomarkers can overcome the limitations of traditional risk factors, enabling precise risk stratification and inflammatory phenotyping, which are crucial for guiding precision interventions.

Moving from single-pathway blockade to phenotype-specific, network-level precision immunomodulation is the key to addressing the heterogeneity of clinical efficacy in CVD treatment.

We present the Chinese Multi-omics Advances In Sepsis (CMAISE) cohort, a prospective, multicenter initiative integrating high-resolution multi-omics (transcriptomics, proteomics, metabolomics, scRNA-seq) with deep clinical phenotyping.

Background: Cervical cancer remains a leading cause of cancer-related morbidity and mortality in Africa, where progress toward WHO’s 90–70–90 elimination targets has been limited by structural health inequalities and gaps in prevention services.

Methods: We conducted a comprehensive analysis of cervical cancer burden across the African Union from 1990 to 2023, using data from the Global Burden of Disease Study 2023. Four key indicators—incidence, prevalence, mortality, and disability-adjusted life years (DALYs)—were extracted and stratified by region and age group. Estimated Annual Percentage Change (EAPC) was calculated to assess long-term trends, while age-specific and regional disparities were evaluated. Future burden was projected to 2038 using the Autoregressive Integrated Moving Average (ARIMA) model.

Results: While global cervical cancer rates have declined modestly since 1990, Africa has experienced rising trends across all indicators. From 1990 to 2023, the age-standardised incidence rate in the African Union rose from 17.41 to 23.53 per 100,000 population (EAPC = 0.67, 95% CI: 0.48–0.87), and DALYs increased from 368.58 to 430.7 per 100,000 (EAPC = 0.24, 95% CI: 0.07–0.41). Central, Southern, and Eastern Africa showed the highest burden, with Southern Africa recording the most rapid increase in incidence (EAPC = 1.54). Age-specific analysis revealed a concentrated burden among women aged 40–54, with absolute case numbers nearly doubling in this group since 1990. Projections suggest a substantial increase in incidence, prevalence, deaths and DALYs by 2038, and the gap between Africa and the global average is expected to widen further, with incidence rates remaining significantly above the WHO elimination threshold of <4/100,000.

Conclusion: Africa’s cervical cancer burden is increasing and diverging from global progress. Structural health system limitations, insufficient HPV vaccination coverage, and low screening uptake are key contributors. Urgent, region-specific interventions—integrating prevention, screening, and treatment—are essential to reverse current trends and achieve WHO elimination goals.

GAnnoViz a cloud-integrated framework for chromosome-level feature annotation and visualization in biomedical multi-omics. Encompassing 30+ analytical and visualization modules across five key areas: acquisition of species genomic annotations, extraction of genomic features, drawing of gene structures, sliding window annotation, and chromosome-scale visualization of multi-omics. It supports genomic annotation retrieval for 349 species from Ensembl, newly assembled genome with GFF3 or GTF format, and an interactive interface deployed on the HiPlot cloud platform.

In two independent cohorts of 10,938 American and 352,980 UK adults aged ≥45 years, the a body shape index (ABSI) showed consistent and comparative stronger associations with all-cause, cardiovascular, and cancer mortalities among 8 adiposity surrogates. Underlying explanations may involve multiple diseases across diverse systems, notably atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and hypercholesterolemia. And ABSI plays a driving role not only in the transitions from disease-free state to these 4 diseases onset, but also from diseases to death. These findings provide more evidence facilitating development and implementation of clinical guidelines for obesity assessment.