27-Jul-2025 Drought-proof apples? new sugar transport genes make it possible Nanjing Agricultural University The Academy of Science New research reveals that certain sugar transporter genes in apples play a key role in boosting drought resistance while enhancing sugar accumulation. Journal Horticulture Research
27-Jul-2025 A molecular makeover: histone switches drive salt tolerance in peas Nanjing Agricultural University The Academy of Science A new study has decoded how pea plants respond to salt stress through precise epigenetic reprogramming. Journal Horticulture Research
27-Jul-2025 Breakthrough in cancer therapy: targeting mutant p53 with novel inhibitors shows promise FAR Publishing Limited A comprehensive review by researchers at Taylor’s University highlights the oncogenic role of mutant p53 (mutp53) in cancer progression and resistance to therapy. The study explores preclinical and clinical advancements in mutp53-targeting compounds, with APR-246 leading the charge in Phase III trials. These inhibitors aim to restore wild-type p53 function, offering new hope for precision cancer treatment. Journal Current Molecular Pharmacology
27-Jul-2025 TNFα signaling at the crossroads of cancer: unveiling dual roles in tumor progression and therapy FAR Publishing Limited A groundbreaking review in Current Molecular Pharmacology explores the dual roles of Tumor Necrosis Factor-alpha (TNFα) in cancer. Led by Sonal M. Manohar, the study highlights TNFα's complex signaling pathways—activating both pro-survival (NF-κB) and pro-death (apoptosis/necroptosis) mechanisms—and its potential as a therapeutic target. "Understanding TNFα's context-dependent actions is key to unlocking its anticancer potential," said Manohar. Journal Current Molecular Pharmacology
27-Jul-2025 Fangchinoline from traditional Chinese medicine targets T cells in Sjögren’s syndrome, inducing apoptosis via oxidative stress and Akt inhibition FAR Publishing Limited A study led by Yubo Xu at Tongji University reveals that Fangchinoline (Fan), a compound from Stephania tetrandra, triggers oxidative stress-induced DNA damage and apoptosis in Jurkat T cells while inhibiting Akt signaling. This dual mechanism highlights Fan’s potential as a therapeutic agent for Sjögren’s syndrome (SS), where T cell infiltration drives disease progression. Journal Current Molecular Pharmacology
27-Jul-2025 Breakthrough review unveils molecular mechanisms and emerging therapies for sarcopenia in aging populations FAR Publishing Limited A comprehensive review in Current Molecular Pharmacology explores sarcopenia’s molecular pathways and cutting-edge interventions. Led by Priyanka Prajapati and team, the study highlights oxidative stress, mitochondrial dysfunction, and promising treatments like exercise, nutraceuticals, and hormone therapy. "Targeting these pathways could revolutionize sarcopenia management," said Prajapati. Journal Current Molecular Pharmacology
27-Jul-2025 Breakthrough study reveals key mechanism behind therapy-resistant leukemia stem cells FAR Publishing Limited A groundbreaking study in Current Molecular Pharmacology uncovers how deeply quiescent leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) evade therapy by suppressing mitochondrial complex I (MC-1) and relying on fatty acid oxidation (FAO). Led by Dr. Nyam-Osor Chimge and Dr. Michael Kahn, the research identifies the CBP/β-catenin antagonist ICG-001 as a potential strategy to force differentiation and eliminate resistant cells. "Targeting this metabolic vulnerability could revolutionize CML treatment," said Dr. Kahn. Journal Current Molecular Pharmacology
26-Jul-2025 Tomato’s genetic shield against aluminum stress uncovered Nanjing Agricultural University The Academy of Science Acidic soils pose a major threat to crop yields due to toxic aluminum ions, especially in sensitive plants like tomato. Journal Horticulture Research
26-Jul-2025 Designer fungi: Genetic “dial” fine-tunes mycelium from leather-soft to steel-hard Journal of Bioresources and Bioproducts A Journal of Bioresources and Bioproducts study shows that natural variation in Schizophyllum commune, coupled with glycerol or PEG crosslinking, produces films with specific strengths from 0.03–3 MPa·(m³/kg) and elongations up to 98 %, offering a genetic roadmap for sustainable materials. Journal Journal of Bioresources and Bioproducts
25-Jul-2025 Cracking the genome of a rising biofuel star Nanjing Agricultural University The Academy of Science Camelina (Camelina sativa) is gaining global attention as a climate-friendly biofuel crop, yet its limited genetic diversity poses a challenge for crop improvement. Journal Horticulture Research
