This study investigates the susceptibility of African spiny mice (Acomys dimidiatus) to carcinogenesis induced by DMBA/TPA, a common two-stage chemical carcinogenesis model. The research reveals that despite their high regenerative capacity, Acomys exhibits resistance to skin carcinogenesis, showing delayed tumor formation and a distinct benign tumor profile compared to C57BL/6 mice. The study highlights the role of enhanced immune response, higher apoptosis, and inhibition of Wnt/β-catenin signaling in conferring this resistance.

EZH2, the catalytic core of the Polycomb Repressive Complex 2 (PRC2), silences gene expression through H3K27me3 modification and is emerging as a master epigenetic regulator beyond cancer. The review “EZH2 in Non-Cancerous Diseases: Expanding Horizons” by Prof. Lixiang Xue's team, published in Protein & Cell, systematically uncovers EZH2’s multifaceted roles in autoimmune, fibrotic, metabolic, and neurological diseases. The authors propose a CDE3 therapeutic model to advance targeted epigenetic therapy in chronic diseases.

Triterpenes, a diverse family of plant-derived molecules, are increasingly recognized for their potential in medicine, food, and sustainable industry.

Flowering in woody bamboos has long been considered one of botany's great mysteries, due to its rarity, unpredictability, and the eventual death of clumps after blooming. 

Salk Institute scientists developed an improved workflow for characterizing capsids (genome-containing protein cones) in HIV-1 (the most common form of HIV). This novel workflow incorporates advanced technology that will allow scientists to better understand how capsid morphology changes in response to distinct pressures and to pinpoint new, more effective ways to target capsids and treat HIV-1. Importantly, the workflow can also be used to study structural changes in other, non-HIV viruses.

Genes born “from scratch,” known as de novo genes, can transform previously noncoding DNA into functional units that drive evolutionary novelty.

Flower shape is a defining trait of ornamental plants, influencing their aesthetic value and commercial appeal. 

Researchers from Hebei University of Technology have developed an innovative approach to lithium-ion battery management that could significantly improve the safety and performance of electric vehicles. The new method, which estimates a battery's state of charge (SOC) based on its internal core temperature rather than surface temperature, addresses a critical flaw in current battery management systems while requiring less computational resources. SOC estimation—essentially determining how much "fuel" remains in an electric vehicle's battery—is crucial for safe and efficient battery operation. However, current methods typically rely on surface temperature measurements that can be misleading for the accuracy of SOC estimation.

Rheumatoid arthritis has traditionally been framed as a self-contained autoimmune disease confined to joints, yet mounting clinical and molecular evidence now argues that it functions as a hub within an expansive web of interacting disorders. Drawing on 392,423 Finnish residents—12,555 of whom carry an RA diagnosis—disease-wide association scanning traces 1,289 distinct medical events before and after the first rheumatology clinic visit. By coupling survival modelling to systematic nosology, clusters of pre-RA liabilities and post-RA sequelae emerge that dissolve the boundary between “the index disease” and apparently unrelated organ pathology.