Researchers at Fondazione Policlinico Universitario Agostino Gemelli IRCCS have developed a promising machine learning algorithm capable of predicting survival and cause of death for patients with bladder cancer undergoing radical cystectomy.

Lotta Gränse, ophthalmologist and researcher Lund University and Skåne University Hospital in Sweden has demonstrated that eye drops containing cortisone can prevent the development of the very serious eye disease ROP in infants. This has revolutionised treatment and means that the majority of children in Sweden’s Southern Healthcare Region with severe ROP do not need conventional treatment under anaesthesia to avoid serious visual impairment or blindness. The study has been published in the highly ranked journal Ophthalmology.

The development of drug resistance, a natural consequence of cancer progression, has become a major obstacle to effective treatment. Due to the overexpression of drug resistance-related proteins and the distinctive properties of resistant cell membranes, achieving efficient internalization of nanomedicines into these cells remains highly challenging. Surface charge engineering has proven pivotal in nanomedicine design, with electrostatic interaction–mediated membrane anchoring of nanocarriers representing a critical breakthrough for advancing drug-resistant cancer therapy.

Diffusion barrier materials (DBMs) are critical for the stability and efficiency of thermoelectric devices. This study presents a streamlined approach for DBM screening in metal chalcogenide-based devices, substitution energy as a simplified criterion within the conventional DFT-based framework. A device comprising seven pairs of Ag₂Se/MgAgSb legs, with Ni employed as the DBM for the Ag₂Se legs, demonstrates excellent cooling performance.

Flexible electronics is profoundly leading the wave of transformation in fields such as wearable devices, health monitoring, and intelligent robots, and material innovation is undoubtedly the core driving force behind this revolution. As a new type of material prepared by compounding liquid metals (LM) with other materials, LM thin films, with their unique properties, have become an ideal candidate in the field of flexible electronics preparation, laying a solid foundation for the vigorous development of flexible electronics technology.

Patients with Type 1 diabetes (T1D) require accurate and consistent monitoring of their blood glucose levels. Over the past decade, AI models have been explored to tackle this challenge; however, inter-patient variability and large data volumes remain key challenges. In a new study, researchers present BiT-MAML, a model-agnostic algorithm aimed at personalized blood glucose prediction of patients with T1D. This approach overcomes the limitations of existing models and enables precise predictions in real clinical settings.

Compressed air energy storage (CAES) is an effective technology for mitigating the fluctuations associated with renewable energy sources. In this work, a hybrid cogeneration energy system that integrates CAES with high-temperature thermal energy storage and a supercritical CO2 Brayton cycle is proposed for enhancing the overall system performance. This proposal emphasizes system cost-effectiveness, eco-friendliness, and adaptability. Comprehensive analyses, including thermodynamic, exergoeconomic, economic, and sensitivity evaluations, are conducted to assess the viability of the system. The findings indicate that, under design conditions, the system achieves an energy storage density, a round-trip efficiency, an exergy efficiency, a unit product cost, and a dynamic payback period of 5.49 kWh/m3, 58.39%, 61.85%, 0.1421 $/kWh, and 4.81 years, respectively. The high-temperature thermal energy storage unit, intercoolers, and aftercooler show potential for optimization due to their suboptimal exergoeconomic performance. Sensitivity evaluation indicates that the operational effectiveness of the system is highly sensitive to the maximum and minimum air storage pressures, the outlet temperature of the high-temperature thermal energy storage unit, and the isentropic efficiencies of both compressors and turbines. Ultimately, the system is optimized for maximum exergy efficiency and minimum dynamic payback period. These findings demonstrate the significant potential of this system and provide valuable insights for its design and optimization.