Article Highlights
Updates every hour. Last Updated: 1-Apr-2026 11:15 ET (1-Apr-2026 15:15 GMT/UTC)
Leaf-inspired bandage heals, hints and vanishes
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
Rubber-tree fat reveals hidden pharmacy: Furan fatty acid found in every clone
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
Cellulose sutures step toward clinic: Green threads promise to mend, then melt away
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
From waste to wardrobe: Spent metal-capturing aerogel reborn as luxury-leather tanning agent
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
Wastewater-to-algae math breaks new ground
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
Bamboo sips in: all-natural drinking straw ready for mass market
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
Fashion’s next fiber frontier: US crop waste spun into sustainable textiles
Journal of Bioresources and Bioproducts- Journal
- Journal of Bioresources and Bioproducts
New mechanism of pluripotency exit in porcine embryonic stem cells for breeding and regenerative medicine
KeAi Communications Co., Ltd.This study uncovers a new molecular mechanism by which the E3 ubiquitin ligase PIAS4 orchestrates pluripotency exit and lineage commitment in porcine embryonic stem cells (pESCs). Using a genome-wide CRISPR screening approach, the researchers identified PIAS4 as a critical regulator that modulates histone H3K4me3 marks via SUMOylation-mediated stabilization of KDM5B. Loss of PIAS4 impaired stem cell differentiation, disrupted lineage specific gene programs, and altered mesendoderm specification through LEFTY2–SMAD signaling. These findings not only provide fundamental insight into porcine stem cell biology but also pave the way for applications in livestock breeding, artificial meat production, and regenerative medicine.
- Journal
- Fundamental Research
- Funder
- National Key Research and Development Program of China, Scientific Innovation 2030 Project, Natural Science Foundation of Hubei Province, Fundamental Research Funds for the Central Universities, Special Research Project on Experimental Animal of Hubei Province
Metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma
KeAi Communications Co., Ltd.This study developed a metal-drug self-delivery nanomedicine (FDAH) to enhance chemotherapy/chemodynamic therapy for hepatocellular carcinoma (HCC). Leveraging a core of iron-based nanoparticles co-loaded with two clinical drugs, Doxorubicin (DOX) and Plerixafor (AMD3100), and an outer shell of hyaluronic acid (HA), the system enables targeted drug delivery and combats therapeutic resistance. After intravenous administration, the HA shell prolongs blood circulation, facilitating tumor accumulation via the EPR effect and subsequent cellular uptake through HA/CD44-specific interactions. Inside tumor cells, the iron ions mediate chemodynamic therapy by triggering the Fenton reaction to generate reactive oxygen species (ROS), which disrupts redox homeostasis and sensitizes cells to DOX. Simultaneously, AMD3100 blocks the CXCL12/CXCR4 axis to alleviate immunosuppression and enhance chemotherapeutic efficacy. This work demonstrates that targeting the immunosuppressive microenvironment with a CXCR4-inhibiting nanoplatform can effectively synergize chemotherapy and chemodynamic therapy for improved HCC treatment.
- Journal
- Fundamental Research
- Funder
- Beijing Natural Science Foundation, National Natural Science Foundation of China, Guangdong Basic and Applied Basic Research Foundation, Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences, Science and Technology Program of Guangzhou